Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males — ASN Events
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  3. Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males

Comparative effect of intraduodenal and intrajejunal glucose infusion on the gut-incretin axis response in healthy males (#70)

Tongzhi Wu 1 2 , Sony S Thazhath 1 2 , Chinmay S Marathe 1 2 , Michelle J Bound 1 2 , Karen L Jones 1 2 , Michael Horowitz 1 2 , Christopher K Rayner 1 2
  1. Discipline of Medicine, The University of Adelaide, Adelaide, South Australia, Australia
  2. Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide, South Australia, Australia

Background/Objectives: The region of enteral nutrient exposure may be an important determinant of postprandial incretin hormone secretion and blood glucose homeostasis. We compared responses of plasma glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin and glucagon, and blood glucose to a standardised glucose infusion into the proximal jejunum and duodenum in healthy humans.

Subjects/Methods: 10 healthy males were evaluated during a standardised glucose infusion (2kcal/min over 120min) into the proximal jejunum (50cm post-pylorus) and were compared with another 10 healthy males matched for ethnicity, age, and BMI who received an identical glucose infusion into the duodenum (12cm post-pylorus). Blood was sampled frequently for measurements of blood glucose and plasma hormones.

Results: Plasma GLP-1, GIP and insulin responses, as well as the insulin:glucose ratio and the insulinogenic index 1 (IGI1) were greater (P<0.05 for each) after intrajejunal than intraduodenal glucose infusion, without a significant difference in  blood glucose or plasma glucagon. Pooled analyses revealed direct relationships between IGI1 and the responses of GLP-1 and GIP (r=0.48 and 0.56 respectively, P<0.05 each), and between glucagon and GLP-1 (r=0.70, P<0.001).

Conclusions: Intrajejunal glucose elicits greater incretin hormone and insulin secretion than intraduodenal glucose in healthy humans, suggesting regional specificity of the gut-incretin axis. 

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