Relationships of ‘Early’ And ‘Late’ Glycaemic Responses With Gastric Emptying During An Oral Glucose Tolerance Test In Subjects With Normal Glucose Tolerance, Impaired Glucose Tolerance And Type 2 Diabetes — ASN Events
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  3. Relationships of ‘Early’ And ‘Late’ Glycaemic Responses With Gastric Emptying During An Oral Glucose Tolerance Test In Subjects With Normal Glucose Tolerance, Impaired Glucose Tolerance And Type 2 Diabetes

Relationships of ‘Early’ And ‘Late’ Glycaemic Responses With Gastric Emptying During An Oral Glucose Tolerance Test In Subjects With Normal Glucose Tolerance, Impaired Glucose Tolerance And Type 2 Diabetes (#285)

Chinmay S Marathe 1 , Michael Horowitz 1 , Laurence Trahair 1 , Judith Wishart 1 , Michelle Bound 1 , Scott Standfield 1 , Kylie Lange 1 , Christopher K Rayner 1 , Karen Jones 1
  1. Discipline of Medicine , Endocrine & Metabolic Unit, Royal Adelaide Hospital / University of Adelaide , Adelaide , SA, Australia

2048-figure%20OGTT%20ADS%20abstract%202015%20copy.jpgGastric emptying (GE), which exhibits a substantial inter-individual variation, is an important determinant of postprandial glycaemia. While the ‘early’ (30 min) glycaemic response during a 75g OGTT is related directly to the rate of GE in health and type 2 diabetes (T2D), there is little information about the impact of GE on the 60 min (a predictor of T2D) or 120 min (used diagnostically) blood glucose.

We evaluated the relationships between glycaemic responses at 30,60 and 120 min and GE following a 75g OGTT in subjects with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and T2D.

82 subjects without diabetes (57 NGT, 35 IGT) and 16 with T2D (managed by diet alone) consumed a 75g glucose drink labelled with 20 MBq of 99m Tc-sulphur colloid over 3 min. GE (by scintigraphy) and glycaemia were measured from t= 0 to 120 min.  The 50% gastric emptying time (T50) was calculated and relationships of blood glucose with GE at 30,60 and 120 min as well as iAUC0-120 determined.

There was no difference in GE between the three groups (1.48 ± 0.04 NGT vs. 1.40 ± 0.08 IGT vs. 1.60 ± 0.1, kcal/min, P=0.11).  A direct relationship between 30 min blood glucose and GE (NGT r=0.40, P<0.01; IGT r=0.49, P=0.02; T2D r=0.62, P=0.01) was seen in all three groups. There was also a direct relationship between 60 min blood glucose and GE in both IGT (r=0.52, P=0.02) and T2D (r=0.77, P<0.01), but not in NGT (r=0.16, P=0.24). In the NGT group, there was an inverse relationship between 120 min blood glucose and GE (r=-0.30, P=0.02), but no significant relationship in either the IGT (r=0.05, P=0.82) or T2D (r=0.37, P=0.16) groups. There was a direct relationship between the ‘overall’ glycaemic response (iAUC0-120 min) and GE in the IGT (r=0.47, P=0.03), but not in NGT (r=0.18, P=0.16) or T2D (r=0.24, P=0.37) groups.

We conclude that gastric emptying is a major determinant of the glycaemic response to an OGTT in NGT, IGT and T2D, but that these relationships differ amongst the groups and are time-dependent, probably reflecting differences in insulin secretion and sensitivity.  

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